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January 1, 2017Cardiorenal Medicine

Long-term peritoneal dialysis was associated with stable left ventricular structure and systolic function, but a progressive decline in diastolic function over 3 years (e' velocity decreased from 9.42 to 7.47 cm/s, p<0.001).

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Why the study?

Does long-term peritoneal dialysis affect left ventricular structure and function in ESRD patients?

Population

40 patients with end-stage renal disease who underwent peritoneal dialysis catheter insertions from January…

Design

Cohort, All echocardiographic measurements were performed by experienced…

Follow-up

3 years

Key result

Long-term peritoneal dialysis was associated with stable left ventricular structure and systolic function, but a progressive decline in diastolic function over 3 years (e' velocity decreased from 9.42 to 7.47 cm/s, p<0.001).

Authors

QSQiuhong ShiJZJing ZhuSFSheng Feng

Discussion

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Overview

May warrant serial diastolic monitoring in long-term PD; leaves open causal mechanisms and intervention targets.

Study Design

Type

Observational (n=40)

Multicenter

No

Structured PICO

Does long-term peritoneal dialysis affect left ventricular structure and function in ESRD patients?

P
Population
40 adult patients with end-stage renal disease on continuous ambulatory peritoneal dialysis, followed for 3 years with annual echocardiography.
E
Exposure
Long-term maintenance peritoneal dialysis (PD)
O
Outcome
Dynamic changes of left ventricular (LV) structure and function (LV mass/height2.7, IVST, LVPWT, EF, E/A ratio, e', E/e' ratio, LAD, LADI) measured by echocardiography at 12-month intervals over 3 yearssurrogate

Main Result

p-value: p=<0.001

In long-term peritoneal dialysis patients, left ventricular structure and systolic function remain stable over 3 years, while diastolic function progressively declines.

Limitations

  • Single-center observational study with a small sample size
  • Only employed resting echocardiography rather than combining data with stress echocardiography, so cardiac functional reserve was not assessed

Cite This Study

Shi et al. (2017) conducted an observational in End-stage renal disease on peritoneal dialysis (n=40). Long-term peritoneal dialysis vs. Baseline (0 months) was evaluated on Changes in left ventricular diastolic function (e' velocity) over 3 years (p=<0.001). Long-term peritoneal dialysis was associated with stable left ventricular structure and systolic function, but a progressive decline in diastolic function over 3 years (e' velocity decreased from 9.42 to 7.47 cm/s, p<0.001).

synapsesocial.com/papers/6a8dc5950b453ccb7788e91chttps://doi.org/10.1159/000466708
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardiac Function and Structure in Longitudinal Analysis of Echocardiography in Peritoneal Dialysis Patients2010 · 17 citations
  2. 2Effect of Peritoneal Dialysis Treatment on Left Ventricular Systolic and Diastolic Functions in Patients with End-Stage Renal Disease2014
  3. 3Alteration of Cardiovascular Structure and Function in Patients Undergoing Peritoneal Dialysis2015 · 7 citations
  4. 4A longitudinal study of cardiac structure and function using echocardiography in patients undergoing peritoneal dialysis2021 · 10 citations
  5. 5Volume Control Associated with Better Cardiac Function in Long-Term Peritoneal Dialysis Patients2006 · 49 citations