Key result
Complete inactivation of the neonatal Fc receptor gene FCGRT in human cells led to a loss of sensitivity to Echoviruses 1, 6, 7, 11, 12, 25, 30, and enterovirus 75.
Inactivation of the FCGRT gene in human cells eliminates their sensitivity to several non-pathogenic enteroviruses.
Suggests a potential genetic target for preventing enteroviral infections; leaves open.
In this work, the influence of the expression levels of the neonatal Fc receptor (FcRn) on the sensitivity of the human transformed and tumor cells to 15 non-pathogenic strains of human enteroviruses was shown. The Complete inactivation of the neonatal fc receptor gene FCGRT in cells led to loss of the sensitivity to Echoviruses 1, 6, 7, 11, 12, 25, 30, enterovirus 75.
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Peter M. Chumakov (2020) studied this question. Complete inactivation of the neonatal Fc receptor gene FCGRT in human cells led to a loss of sensitivity to Echoviruses 1, 6, 7, 11, 12, 25, 30, and enterovirus 75.
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