High-level resistance to aminoglycosides mediated by the production of 16S rRNA methylase among various gram-negative pathogens has been increasingly reported ([4][1]). Six 16S rRNA methylase enzymes have been identified: RmtA to RmtD, ArmA, and NpmA ([4][1], [9][2]). We recently described the
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Doi et al. (2008) studied this question.
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