Key result
Traditional Chinese medicine can regulate key molecules in inflammatory signaling pathways, treating diabetic kidney disease inflammation and injury through multiple mechanisms.
Traditional Chinese medicine may offer a multi-target approach to treating diabetic kidney disease by modulating key inflammatory signal transduction pathways.
Highlights inflammation as a therapeutic target in diabetic kidney disease; leaves open whether inhibiting NF-κB.
Inflammatory injury is a critical factor in the occurrence and development of diabetic kidney disease (DKD). Signal transduction pathways such as the nuclear factor kappa beta (NF-κB), mitogen-activated protein kinase (MAPK), NOD-like receptor protein 3, and Smads are important mechanisms of inflammatory kidney injury in DKD, and the NF-κB pathway plays a key role. The inflammatory factor network formed after activation of the NF-κB pathway connects different signaling pathways and exacerbates renal inflammatory damage. Many traditional Chinese medicine compounds, single agents, effective components and active ingredients can regulate the expression of key molecules in the signaling pathways associated with inflammatory injury, such as transforming growth factor-β activated kinase 1, NF-κB, p38MAPK, NOD-like receptor protein 3, and Smad7. These treatments have the characteristics of multiple targets and have multiple and overlapping effects, which can treat DKD kidney inflammation and injury through multiple mechanisms and apply the "holistic concept" of traditional Chinese medicine.
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Li et al. (2024) conducted a review in Diabetic kidney disease. Traditional Chinese medicine was evaluated. Traditional Chinese medicine can regulate key molecules in inflammatory signaling pathways, treating diabetic kidney disease inflammation and injury through multiple mechanisms.
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