Key result
Previous transient ischemic attack was not associated with differences in independence at 3 months following thrombolysis for acute ischemic stroke (OR 1.035; 95% CI 0.57-1.93; P=0.91).
Why the study?
Does a recent prior transient ischemic attack influence clinical outcomes or bleeding risk following intravenous thrombolysis in patients with acute ischemic stroke?
Population
877 consecutive acute ischemic stroke patients treated with intravenous tissue plasminogen activator, of…
Comparison
Intravenous tissue plasminogen activator in… vs Intravenous tissue plasminogen activator in…
Design
Cohort
Follow-up
3 months
Authors
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Prior TIA need not alter thrombolysis decisions in acute stroke; this Level 3 evidence leaves open confirmation in randomized trials.
Cohort (n=877)
Yes
Does a recent prior transient ischemic attack influence clinical outcomes or bleeding risk following intravenous thrombolysis in patients with acute ischemic stroke?
Odds Ratio: 1.035 (95% CI 0.57–1.93)
p-value: p=0.91
A recent transient ischemic attack prior to an acute ischemic stroke does not significantly alter the efficacy or bleeding risk of intravenous thrombolysis.
Fuentes et al. (2011) conducted a cohort in Acute ischemic stroke (n=877). Previous ipsilateral transient ischemic attack vs. No previous transient ischemic attack was evaluated on Independence (modified Rankin Scale 0-2) at three-months (OR 1.035, 95% CI 0.57-1.93, p=0.91). Previous transient ischemic attack was not associated with differences in independence at 3 months following thrombolysis for acute ischemic stroke (OR 1.035; 95% CI 0.57-1.93; P=0.91).
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