Key result
Molecular mechanisms interacting with the basic genotype of the muscle cell explain the pleiotropic alterations observed in contractile protein isoforms.
Advances in delineating molecular mechanisms are expected to provide greater insight into the genetic control of contractile protein expression.
Does not yet guide clinical decisions in muscle disorders; leaves open targeted genetic therapies pending translational validation.
The pleiotropic alterations in contractile protein isoforms can be explained by the interaction of only a few molecular mechanisms with the basic genotype of the muscle cell. Rapid advances in delineating the details of these mechanisms can be expected to provide greater insight into the genetic control of contractile protein expression than might have been anticipated only a few years ago.
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Eugene Morkin (1987) studied this question. Molecular mechanisms interacting with the basic genotype of the muscle cell explain the pleiotropic alterations observed in contractile protein isoforms.
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