Answers are grounded in this paper and cite their sources.
A study of the guanidination of ovalbumin with 1-guanyl-3,5-dimethyl pyrazole nitrate showed that at pH 9.5 the reagent reacts specifically with the ε-amino groups of lysine. Guanidination did not produce configurational changes that could be detected by sedimentation, diffusion, or electrophoresis.
No takes yet. Share an insight, caveat, or question.
A.F.S.A. Habeeb (1961) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: