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The method outlined by Archibald for handling transient data in equilibrium ultracentrifugation yields a molecular weight for lysozyme that conforms to those given by other methods. A method for applying the Archibald procedure to apurinic acid which is polydisperse and has a concentration dependent sedimentation rate is outlined. The use of a mechanical integrator for reducing the computational work is described.
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Smith et al. (1956) studied this question.
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