What question did this study set out to answer?

To develop an artificial colorimetric probe based on a phenolphthalein scaffold capable of selectively recognizing acetate anions and neutral organic molecules in pure water.

September 17, 2026Canadian Journal of Chemistry

A colorimetric chemosensor for the rapid detection of acetate anion and neutral molecules in water

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Authors

YGYongsheng Guo JWJianmin Wang XSXinyu Song

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Overview

Experimental study demonstrates rapid colorimetric detection of acetate and neutral molecules in pure water, highlighting a hydrogen bond-induced proton transfer mechanism.

Key Points

To develop an artificial colorimetric probe based on a phenolphthalein scaffold capable of selectively recognizing acetate anions and neutral organic molecules in pure water.
Designed and synthesized a novel colorimetric chemosensor incorporating a phenolphthalein core.
Conducted UV–vis titration experiments in pure water to quantify binding affinities toward acetate anions and multiple neutral organic solvents.
Evaluated the correlation between solvent lipophilicity (logP) and binding strength to elucidate the recognition mechanism.
The probe demonstrated high binding affinity for acetate in pure water, with an association constant of β2 ≈ 3.3 × 10^6 M^-2 and a distinct color change.
Binding affinities for neutral organic solvents ranged from 0.1 to 1159 M^-2, with affinity increasing as lipophilicity decreased for solvents with negative logP values.
Mechanistic analysis established that sensing occurs via hydrogen bond-induced proton transfer involving an intramolecular O···H–N interaction and phenolphthalein tautomerism.

Cite This Study

Guo et al. (2026) studied this question.

synapsesocial.com/papers/6aabb6d85f706d05830e57dc https://doi.org/10.1139/cjc-2026-0116

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September 17, 2026Canadian Journal of Chemistry

A colorimetric chemosensor for the rapid detection of acetate anion and neutral molecules in water

View Full Paper

Ask AI

Bookmark

Authors

YGYongsheng Guo JWJianmin Wang XSXinyu Song

Discussion

Member takes

Overview

Experimental study demonstrates rapid colorimetric detection of acetate and neutral molecules in pure water, highlighting a hydrogen bond-induced proton transfer mechanism.

Key Points

To develop an artificial colorimetric probe based on a phenolphthalein scaffold capable of selectively recognizing acetate anions and neutral organic molecules in pure water.
Designed and synthesized a novel colorimetric chemosensor incorporating a phenolphthalein core.
Conducted UV–vis titration experiments in pure water to quantify binding affinities toward acetate anions and multiple neutral organic solvents.
Evaluated the correlation between solvent lipophilicity (logP) and binding strength to elucidate the recognition mechanism.
The probe demonstrated high binding affinity for acetate in pure water, with an association constant of β2 ≈ 3.3 × 10^6 M^-2 and a distinct color change.
Binding affinities for neutral organic solvents ranged from 0.1 to 1159 M^-2, with affinity increasing as lipophilicity decreased for solvents with negative logP values.
Mechanistic analysis established that sensing occurs via hydrogen bond-induced proton transfer involving an intramolecular O···H–N interaction and phenolphthalein tautomerism.

Cite This Study

Guo et al. (2026) studied this question.

synapsesocial.com/papers/6aabb6d85f706d05830e57dc https://doi.org/10.1139/cjc-2026-0116

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