Key result
CABG surgery significantly decreased muscle protein synthesis rates (0.97 vs 1.59 %/day; P<0.001) but increased synthesis of fibrinogen and albumin 4 hours post-surgery.
Why the study?
Does CABG surgery alter the synthesis rates of muscle protein, fibrinogen, and albumin in patients undergoing the procedure?
Observational (n=12)
Does CABG surgery alter the synthesis rates of muscle protein, fibrinogen, and albumin in patients undergoing the procedure?
CABG surgery induces an acute differential protein metabolic response, characterized by decreased muscle protein synthesis and increased hepatic acute-phase protein synthesis.
The aim of the present study was to investigate the acute effect of CABG (coronary artery bypass graft) surgery on the rates of synthesis of muscle protein, the positive acute-phase protein fibrinogen and the negative acute-phase protein albumin. Synthesis rates of muscle protein, fibrinogen and albumin were measured simultaneously before and 4 h after the end of surgery from the incorporation of L-[(2)H(5)]phenylalanine (given at 43 mg/kg of body weight) in 12 patients undergoing CABG surgery. Surgery was performed either with the use of extracorporeal circulation with cardiopulmonary bypass (on-pump; n=5) or with the beating heart procedure without cardiopulmonary bypass (off-pump; n=7). Post-surgical muscle protein fractional synthesis rates were decreased by 36+/-6.5% compared with pre-surgical values (1.59+/-0.10 compared with 0.97+/-0.08%/day respectively; P<0.001). In contrast, the synthesis rates of both fibrinogen (36+/-4 compared with 100+/-11 mg.day(-1).kg(-1) of body weight; P<0.0001) and albumin (123+/-12 compared with 178+/-19 mg.day(-1).kg(-1) of body weight; P<0.001) were both significantly increased after surgery. No significant differences were found between surgery performed with or without cardiopulmonary bypass. In conclusion, the results demonstrate that CABG surgery has a profound effect on protein metabolism, with a differential response of protein synthesis in muscle and liver.
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Caso et al. (2008) conducted an observational in Coronary artery bypass graft (CABG) surgery (n=12). CABG surgery vs. Pre-surgical baseline was evaluated on Muscle protein fractional synthesis rates (%/day) (p=<0.001). CABG surgery significantly decreased muscle protein synthesis rates (0.97 vs 1.59 %/day; P<0.001) but increased synthesis of fibrinogen and albumin 4 hours post-surgery.
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