Key result
Undifferentiated connective tissue disease during pregnancy is associated with a high risk of complications, including preeclampsia, premature birth, and bleeding, which are exacerbated by magnesium deficiency.
Why the study?
Generalized connective tissue damage involving the reproductive system significantly affects pregnancy and delivery, but reliable diagnostic criteria for undifferentiated connective tissue disease are lacking.
This review highlights the impact of undifferentiated connective tissue disease on pregnancy complications and advocates for comprehensive diagnostic approaches including magnesium assessment.
Suggests undifferentiated connective tissue disease may increase obstetric surgical risk; leaves open whether targeted cardiovascular or.
This paper discusses connective tissue disorders (CTD), in particular, undifferentiated connective tissue disease (UCTD) whose importance is accounted for by a high prevalence of this condition. Generalized connective tissue damage that involves reproductive system significantly affects the course of pregnancy and delivery. The complications of pregnancy, delivery, and postpartum period in women with UCTD which often require surgical procedures (i.e., amniotomy, episiotomy, perineotomy, C-section etc.) are described. The paper highlights the role of magnesium which is of crucial importance for the complex biosynthesis of extracellular matrix during connective tissue formation and fibroblast morphological functional status. The tests for connective tissue metabolic disorders (blood oxyproline and fibronectin, urine pyrilinks-D and glycosaminoglycans etc.) are addressed. Considering the lack of the reliable diagnostic (biochemical and genetic) criteria for UCTD, the authors advocate the need for a complex examination using anamnestic data and the results of clinical, instrumental, and laboratory tests.KEYWORDS: connective tissue disorders, hemostasis, complications of pregnancy and delivery, magnesium deficiency, endothelial dysfunction, markers of collagen degradation, genital prolapse.FOR CITATION: Il’ina I.Yu., Chikisheva A.A. Course of the pregnancy in women with connective tissue disorders. Russian Journal of Woman and Child Health. 2020;3(3):182–188. DOI: 10.32364/2618-8430-2020-3-3-182-188
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Il’ina et al. (2020) conducted a review in Undifferentiated connective tissue disease (UCTD) in pregnancy. Undifferentiated connective tissue disease and magnesium deficiency was evaluated. Undifferentiated connective tissue disease during pregnancy is associated with a high risk of complications, including preeclampsia, premature birth, and bleeding, which are exacerbated by magnesium deficiency.
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