March 1, 1965Journal of BacteriologyOpen Access

Effect of Enzymes on the Interaction of Enteroviruses with Living HeLa Cells

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Population

Living HeLa cells

Comparison

Eight crude enzyme preparations and two… vs Untreated cells or comparison between different…

Design

Preclinical

Authors

RCRichard L. CrowellDrexel University

Discussion

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Implication

Differential enzyme effects on viral attachment observed in vitro; leaves open whether receptor inactivation can be exploited therapeutically in humans.

Structured PICO

Population

Living HeLa cells

Intervention

Eight crude enzyme preparations and two crystalline enzymes (including elastase, pancreatin, chymotrypsin, trypsin, receptor-destroying enzyme, erepsin, lysozyme, collagenase, proteinase, and cobra venom) in 1% solutions

Comparator

Untreated cells or comparison between different enzymes

Outcome

Ability to inactivate coxsackie group B and poliovirus receptors (attachment and dissociation of viruses)surrogate

Cellular receptors for polioviruses differ from those for group B coxsackie-viruses, and specific enzymes can differentially inactivate these enteroviral receptors without altering cell viability.

Cite This Study

Richard L. Crowell (1965) studied this question.

synapsesocial.com/papers/6a8e7b6034f2e8bd0f1d6760 https://doi.org/10.1128/jb.89.3.574-582.1965

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Implication

Differential enzyme effects on viral attachment observed in vitro; leaves open whether receptor inactivation can be exploited therapeutically in humans.

Effect of Enzymes on the Interaction of Enteroviruses with Living HeLa Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effect of Enzymes on the Interaction of Enteroviruses with Living HeLa Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider