October 13, 1998Proceedings of the National Academy of SciencesOpen Access

Complex gangliosides are essential in spermatogenesis of mice: Possible roles in the transport of testosterone

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Population

Mice, homozygous for disrupted ganglioside GM2/GD2 synthase gene and lacking all complex gangliosides

Comparison

Disruption of ganglioside GM2/GD2 synthase gene vs Wild-type mice

Design

Preclinical

Authors

KTKogo TakamiyaUniversity of Miyazaki AYAkihito YamamotoNippon Medical School KFKeiko FurukawaChubu University

Discussion

Member takes

Implication

Complex gangliosides support testosterone transport and spermatogenesis in mice; hypothesis-generating for human male infertility with no clinical implications yet.

Structured PICO

Population

Mice, homozygous for disrupted ganglioside GM2/GD2 synthase (EC 2.4. 1.94) gene and lacking all complex gangliosides

Intervention

Disruption of ganglioside GM2/GD2 synthase gene

Comparator

Wild-type mice

Outcome

Spermatogenesis and testosterone transportsurrogate

Complex gangliosides are essential for testosterone transport and spermatogenesis in mice.

Cite This Study

Takamiya et al. (1998) studied this question.

synapsesocial.com/papers/6a8e8404bd6f846da2ffeaf6 https://doi.org/10.1073/pnas.95.21.12147

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Implication

Complex gangliosides support testosterone transport and spermatogenesis in mice; hypothesis-generating for human male infertility with no clinical implications yet.

Complex gangliosides are essential in spermatogenesis of mice: Possible roles in the transport of testosterone

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Complex gangliosides are essential in spermatogenesis of mice: Possible roles in the transport of testosterone

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider