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The unequivocal syntheses of four cis-[PtL2{(O2C)2CH(CH2)nCO2H}] complexes [L2=(NH3)2 or trans-cyclohexane-1,2-diamine, n= 1 or 4] has been achieved, avoiding any interaction between the pendant carboxyl group and the platinum. The complexes have been characterized by elemental analysis, 13C NMR and FAB mass spectroscopy. Their interaction with a tetradeoxyribonucleotide d(T-G-G-T)(G = guanosine, T = ribosylthymine) and DNA (in vitro) has been investigated to show that they form adducts of the type [PtL2{(GpG)-N7,N7′}] as do known therapeutically active platinum complexes. However the presence of the free carboxyl function increases significantly the reactivity with respect to that of the related non-functionalized malonato complexes [PtL2{H2C(CO2)2}].
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Laurent et al. (1993) studied this question.
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