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Chronic exposure to Mn3O4 in the diet at 1050 ppm Mn retarded the sexual development and lowered reactive locomotor activity levels in male mice. A multivariate analysis of variance indicated that testis, seminal vesicle, and preputial gland weights were significantly smaller as a result of Mn administration. These results support earlier observations of altered locomotor activity levels and reproductive development in male rats in the absence of other signs of toxicity.
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Gray et al. (1980) studied this question.
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