What does this research mean for the field?

Amelogenesis imperfecta exhibits distinct phenotype-related differences in clinical manifestations, with the hypoplastic phenotype being the most prevalent and the hypocalcified phenotype showing the highest frequency of hypersensitivity, periodontal disease, and crossbite. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To characterize and compare the clinical, enamel, and radiographic features across different amelogenesis imperfecta phenotypes in pediatric patients.

August 26, 2026THE JOURNAL OF THE KOREAN ACADEMY OF PEDTATRIC DENTISTRYOpen Access

Clinical, Enamel, and Radiographic Features of Amelogenesis Imperfecta in Pediatric Patients: A Multicenter Study

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To characterize and compare the clinical, enamel, and radiographic features across different amelogenesis imperfecta phenotypes in pediatric patients.
Retrospective multicenter study reviewing records of pediatric patients (N=39, aged < 18 years) diagnosed with amelogenesis imperfecta across 11 university dental hospitals in Korea (2022–2025).
Patients were categorized into hypoplastic, hypomaturation, and hypocalcified phenotypes using the Witkop classification, and phenotypic group differences were evaluated using the Monte Carlo version of Fisher's exact test.
The hypoplastic phenotype was the most prevalent (53.8%), followed by hypomaturation (28.2%) and hypocalcified (17.9%), with a mean age at initial presentation of 9.62 ± 3.48 years.
Dental hypersensitivity, periodontal disease, and crossbite differed significantly across phenotypes, occurring with the highest frequency in the hypocalcified group.
Hypoplastic cases predominantly exhibited white-yellow discoloration, pitting, and reduced enamel thickness, whereas all hypocalcified cases displayed yellow-brown discoloration, enamel wear, and decreased radiopacity; taurodontism was the most frequent overall radiographic anomaly.

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Implication

Multicenter retrospective study reveals significant phenotypic variations in enamel defects and dental complications in pediatric amelogenesis imperfecta, highlighting the need for phenotype-based...

Cite This Study

Yin et al. (2026) studied this question.

synapsesocial.com/papers/6a8e9b68451774b83f3b41be https://doi.org/10.5933/jkapd.2026.53.3.297

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Implication

Multicenter retrospective study reveals significant phenotypic variations in enamel defects and dental complications in pediatric amelogenesis imperfecta, highlighting the need for phenotype-based...

Clinical, Enamel, and Radiographic Features of Amelogenesis Imperfecta in Pediatric Patients: A Multicenter Study

Key Points

Discussion

Implication

Cite This Study

Clinical, Enamel, and Radiographic Features of Amelogenesis Imperfecta in Pediatric Patients: A Multicenter Study

Key Points

Discussion

Implication

Cite This Study

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