Novel NKX2-5 mutation associated with familial atrial septal defects and atrial and ventricular arrhythmias

Figures

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  Figure 1. 12-Lead electrocardiogram (ECG). The baseline ECG shows sinus bradycardia at 56 beats/min, with first-degree atrioventricular block (PR interval 278 ms), a QRS duration of 106 ms, and nonspecific repolarization abnormalities.

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  Figure 2. 3-dimensional electroanatomic mapping. Shown are electroanatomic maps of nonautomatic focal atrial tachycardia in right (left panel) and left (right panel) anterior oblique views. Activation times are color-coded from earliest in red to latest in purple. The nonautomatic focal atrial tachycardia was successfully ablated at the location of the red sphere. Also seen is the cavotricuspid ablation line for typical atrial flutter. CS = coronary sinus; IVC = inferior vena cava; SVC = superior vena cava.

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  Figure 3. Nonsustained ventricular tachycardia. A: Brief episodes of nonsustained ventricular tachycardia (4–6 beats) with varying morphologies, occurring in the setting of underlying atrial fibrillation. B: Implantable cardiac monitor recording obtained during palpitations associated with presyncope, demonstrating a 28-beat run of irregular monomorphic ventricular tachycardia with a warm-up pattern and a shortest cycle length of 250 ms.