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All articles of this category Synthesis of naturally occurring ligustilide ( 1 ) was accomplished by the cyclization of alkynoic acid ( 9 ), which was prepared from acetal ( 3 ) in several steps, catalyzed by silver iodide or silver in mild reaction condition as key step. ligustilide - cyclization - silver catalyst - alkynoic acid
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Ogawa et al. (1995) studied this question.
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