Key result
A non-dipping hypertension pattern was significantly associated with advanced chronic kidney disease (stages 3-4 vs 1-2, p=0.018), but not with dyslipidemia or type 2 diabetes.
Why the study?
Is a non-dipping hypertension pattern associated with dyslipidemia, type 2 diabetes, or chronic kidney disease stage in patients with CKD?
Observational (n=129)
No
Is a non-dipping hypertension pattern associated with dyslipidemia, type 2 diabetes, or chronic kidney disease stage in patients with CKD?
p-value: p=0.018
In patients with chronic kidney disease, advanced CKD stage (3-4 vs 1-2) is significantly associated with a non-dipping hypertension pattern, whereas dyslipidemia and type 2 diabetes are not.
Background and aims. Hypertension and dyslipidemia (DLP) increase the risk of cardiovascular diseases (CVD), especially in patients with chronic kidney disease (CKD). A non dipping pattern is very common in CKD. The aim of the study was to determine whether there is a difference between dipping/non dipping hypertension in subjects with CKD and DLP with or without lipid-lowering therapy (LLT). Material and methods. We performed a retrospective study that included 129 subjects from the Nephrology- Hypertension Out-patient Department of the University Campus Bio-Medico, Rome from January 2011 to April 2013. Results. From a total of 129 CKD subjects, 73 (56.59%) subjects had a non dipping pattern and 56 (43.41%) had a dipper pattern. We found statistically significant differences between the dipping and non-dipping pattern in subjects with CKD stages 1-2 versus stages 3-4 (p=0.018). When we analyzed the association between non-dipping status with DLP and type 2 diabetes (T2D), we did not find a statistically significant result. Conclusions. Only CKD significantly influenced the dipping/non dipping pattern in the study group
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Tudor et al. (2013) conducted an observational in Chronic kidney disease and hypertension (n=129). Non-dipping hypertension pattern vs. Dipping hypertension pattern was evaluated on Association of dipping/non-dipping status with CKD stages, dyslipidemia, and type 2 diabetes (p=0.018). A non-dipping hypertension pattern was significantly associated with advanced chronic kidney disease (stages 3-4 vs 1-2, p=0.018), but not with dyslipidemia or type 2 diabetes.
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