In patients with dyslipidemia, a non-dipping blood pressure pattern was associated with a higher prevalence of cardiovascular disease, with the night-day systolic blood pressure ratio significantly increasing CVD risk (OR 1.72).
Cross-Sectional (n=243)
No
Is non-dipping hypertension associated with a higher risk of cardiovascular disease compared to dipping hypertension in patients with dyslipidemia?
Non-dipping hypertension is more strongly associated with cardiovascular disease than dipping hypertension in patients with dyslipidemia.
Odds Ratio: 1.72 (95% CI 1.33–2.06)
valor p: p=<0.001
Introduction: Dyslipidemia combined with hypertension increases the risk of cardiovascular disease (CVD). The current study aimed to investigate the association of dipping and non-dipping hypertension with CVD in patients with dyslipidemia. Material and methods: A total of 243 documented dyslipidemia patients with hypertension were enrolled. Clinical characteristics and clinic and 24hour blood pressure (BP) parameters were compared between dipping and non-dipping groups based on 24-hour ambulatory blood pressure monitoring. Logistic regression analysis was performed to evaluate the association of dipping and non-dipping hypertension with CVD. Results: Compared to the dipping group, patients in the non-dipping group were older, more likely to be male and smokers, had higher serum creatinine levels, and were more likely to have chronic kidney disease and CVD (p < 0.05 for all comparisons). No significant between-group differences in clinic systolic and diastolic BP (SBP and DBP) were observed. However, compared to the dipping group, 24-hour SBP, nighttime SBP and DBP, and night-day ratio of SBP and DBP were all significantly higher in the non-dipping group (p < 0.05 for all comparisons). In the dipping group, only night-day ratio of SBP was significantly associated with CVD, with an odds ratio (OR) of 1.09 (95% confidence interval (CI) of 1.02-1.34). In the non-dipping group, both night-day ratio of SBP and DBP were significantly associated with CVD, with an OR of 1.72 (95% CI: 1.33-2.06) and 1.23 (95% CI: 1.05-1.66), respectively. Conclusions: In patients with dyslipidemia, non-dipping hypertension is more closely related to CVD compared to dipping hypertension.
Dai et al. (Thu,) conducted a cross-sectional in Dyslipidemia with hypertension (n=243). Non-dipping blood pressure pattern vs. Dipping blood pressure pattern was evaluated on Association of night-day ratio of systolic blood pressure with prevalent cardiovascular disease in the non-dipping group (OR 1.72, 95% CI 1.33-2.06, p=<0.001). In patients with dyslipidemia, a non-dipping blood pressure pattern was associated with a higher prevalence of cardiovascular disease, with the night-day systolic blood pressure ratio significantly increasing CVD risk (OR 1.72).
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