Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 26, 2026PharmaceuticalsOpen Access

Real-World Antidepressant Prescribing Patterns and Comparative Safety Outcomes of Commonly Prescribed Antidepressants in Patients with Depressive Disorder: A Multicenter OMOP-CDM Study

View Full Paper
Ask AI
Bookmark
Share

Authors

JMJungha MinSSSueun ShinSPSohyeon Park

Discussion

Loading...

Member takes

Overview

Multicenter observational study demonstrates comparable safety across common antidepressants but elevated QTc prolongation risk with sertraline in depression, suggesting tailored drug selection.

Key Points

  • To characterize real-world prescribing patterns and evaluate the comparative safety of frequently prescribed antidepressants in a multicenter cohort of adults with newly diagnosed depressive disorder.
  • Conducted a retrospective observational study across 18 hospitals using electronic health record data standardized to the OMOP Common Data Model (1999–2026).
  • Mapped prescribing trajectories in 13,381 patients and evaluated comparative safety between escitalopram, sertraline, and trazodone across 44,542 patients using propensity score-matched Cox proportional hazards models and meta-analysis.
  • Selective serotonin reuptake inhibitors were most commonly initiated, led by escitalopram (21.4%, n = 2,868), with frequent adjunctive use of trazodone (14.6%, n = 794) and quetiapine (14.0%, n = 761).
  • Across nine clinical safety outcomes, overall profiles were comparable, though sertraline was associated with a significantly increased risk of QTc prolongation compared to escitalopram (HR 1.75, 95% CI 1.10–2.78).

Cite This Study

Min et al. (2026) studied this question.

synapsesocial.com/papers/6a8ebb54451774b83f3b4c19https://doi.org/10.3390/ph19091332
View Full Paper
Ask AI
Bookmark
Share