Late cardiac effects of anthracycline-based therapy in childhood cancer survivors: a CMR study of cardiac strain and function

Q: What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Childhood cancer survivors (n=196). Intervention: Anthracycline-based therapy vs. Age- and sex-matched controls. Primary outcome: Cardiac strain evaluated with cardiovascular magnetic resonance feature tracking (CMR-FT).

Mary Luz Mojica‐Pisciotti; Roman Panovský; Tomáš Holeček; Věra Feitová; Lukáš Opatřil; Vladimír Kincl; Tomáš Kepák

doi:10.1007/s00392-026-03003-4

August 24, 2026Clinical Research in Cardiology

Late cardiac effects of anthracycline-based therapy in childhood cancer survivors: a CMR study of cardiac strain and function

View Full Paper

Ask AI

Bookmark

Share

Key result

Anthracycline therapy abstract lacks quantitative results on late cardiac strain in childhood cancer survivors.

n=196

Why the study?

Anthracycline-based therapies cause cancer therapy-related cardiac dysfunction in childhood cancer survivors, motivating evaluation of CMR feature tracking strain as a marker of subclinical dysfunction.

Does anthracycline-based therapy cause subclinical changes in cardiac strain evaluated by CMR-FT in childhood cancer survivors?

Key Points

To evaluate the utility of cardiac strain measured by cardiovascular magnetic resonance feature tracking (CMR-FT) as a marker of subclinical cancer therapy-related cardiac dysfunction in childhood cancer survivors treated with anthracyclines.
Cross-sectional observational study including 117 childhood cancer survivors assessed approximately 12 years post-treatment alongside 79 retrospectively selected age- and sex-matched controls.
Cardiovascular magnetic resonance feature tracking (CMR-FT) was used to measure biventricular global longitudinal, circumferential, and radial strain, as well as biatrial longitudinal strain, stratified by cumulative anthracycline dose.
Evaluated subclinical cardiac function across ventricular and atrial strain parameters in long-term childhood cancer survivors.
Identified measurable cardiac strain differences via CMR-FT according to anthracycline exposure relative to healthy matched controls.

Study Design

Type

Cross-Sectional (n=196)

Structured PICO

Does anthracycline-based therapy cause subclinical changes in cardiac strain evaluated by CMR-FT in childhood cancer survivors?

P

Population

196 participants, comprising 117 childhood cancer survivors treated with anthracyclines examined approximately 12 years post-treatment and 79 age- and sex-matched controls.

E

Exposure

Anthracycline-based therapy (historical exposure)

C

Comparator

Age- and sex-matched controls

O

Outcome

Cardiac strain evaluated with cardiovascular magnetic resonance feature tracking (CMR-FT), including global longitudinal strain (GLS), global circumferential strain (GCS), global radial strain (GRS) for both ventricles, and longitudinal strain for both atriasurrogate

Implication

Cross-sectional study reveals subclinical cardiac strain alterations in childhood cancer survivors, highlighting CMR feature tracking for early cardiotoxicity detection.

Abstract

No abstract yet. The journal hasn't published one we can show.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Mojica‐Pisciotti et al. (2026) conducted a cross-sectional in Childhood cancer survivors (n=196). Anthracycline-based therapy vs. Age- and sex-matched controls was evaluated on Cardiac strain evaluated with cardiovascular magnetic resonance feature tracking (CMR-FT).

synapsesocial.com/papers/6a8ebca0451774b83f3b4d44 https://doi.org/10.1007/s00392-026-03003-4

View Full Paper

Ask AI

Bookmark

Share

Late cardiac effects of anthracycline-based therapy in childhood cancer survivors: a CMR study of cardiac strain and function

Key Points

Study Design

Structured PICO

Implication

Abstract

Discussion

Cite This Study

Late cardiac effects of anthracycline-based therapy in childhood cancer survivors: a CMR study of cardiac strain and function

Key Points

Study Design

Structured PICO

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading