Why the study?
Does the NOS2A gene promoter + allele polymorphism influence clinical variables in patients with coronary artery disease?
Observational (n=856)
Does the NOS2A gene promoter + allele polymorphism influence clinical variables in patients with coronary artery disease?
The NOS2A + allele is associated with indices of insulin resistance and increased frequency of unstable angina in male patients with coronary artery disease.
Pathophysiological processes in coronary artery disease (CAD) are influenced by genetic factors. Since (i) inducible nitric oxide synthase (iNOS) has important cardiovascular effects, and (ii) the promoter of the iNOS gene (NOS2A) is genetically modulated by a 4 bp insertion/deletion (+/-) polymorphism located 0.7 kb upstream, we decided to examine the influence of this variant on clinical variables in 856 CAD patients of Anglo-Celtic/Northern European extraction. We found that 2% of CAD patients were homozygous for the + allele, and 19% were heterozygous. Males made up 74% of the patient group, and in these the + allele was associated with 38% higher plasma glucose levels (P=0.005), a 4.8% elevation in the waist/hip ratio (P=0.009) and a 48% greater frequency of unstable angina (P=0.014). The + allele, by influencing iNOS expression, could thus contribute to indices of insulin resistance and angina severity in male CAD patients.
No takes yet. Share an insight, caveat, or question.
Morris et al. (2001) conducted an observational in Coronary artery disease (n=856). NOS2A gene 4 bp insertion/deletion (+/-) polymorphism (+ allele) vs. Absence of the + allele was evaluated on Plasma glucose levels, waist/hip ratio, and frequency of unstable angina.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: