Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 1, 2012PathophysiologyOpen Access

Association of plasma nitric oxide concentration and endothelial nitric oxide synthase T-786C gene polymorphism in coronary artery disease

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Is the eNOS T-786C gene polymorphism associated with an increased risk of coronary artery disease and altered plasma NO concentrations?

Population

502 subjects, comprising 241 unrelated CAD patients with positive coronary angiograms and 261 age-matched…

Comparison

eNOS gene T-786C polymorphism vs Control subjects without symptomatic CAD

Design

Case-control

Authors

SSSaeedeh SalimiANAnoosh NaghaviMFMohsen Firoozrai

Discussion

Loading...

Member takes

Overview

Supports CAD association in case-control data; hypothesis-generating and requires validation before any clinical use.

Structured PICO

Is the eNOS T-786C gene polymorphism associated with an increased risk of coronary artery disease and altered plasma NO concentrations?

P
Population
502 subjects, comprising 241 unrelated CAD patients with positive coronary angiograms and 261 age-matched control subjects without a history of symptomatic CAD
I
Intervention
eNOS gene T-786C polymorphism
C
Comparator
Control subjects without symptomatic CAD
O
Outcome
Presence of coronary artery disease and plasma nitric oxide (NO) concentrationssurrogate

The T-786C polymorphism of the NOS3 gene is associated with coronary artery disease, though it does not appear to be associated with increased plasma NO in CAD patients.

Cite This Study

Salimi et al. (2012) studied this question.

synapsesocial.com/papers/6a72f04bd33c10ecfecf2a84https://doi.org/10.1016/j.pathophys.2012.04.003
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1T<sup>−786</sup>→C Mutation in the 5′-Flanking Region of the Endothelial Nitric Oxide Synthase Gene Is Associated With Coronary Spasm1999 · 783 citations
  2. 2Genetic Risk Factors for Coronary Artery Spasm: Significance of Endothelial Nitric Oxide Synthase Gene T <sup>−786</sup> →C and Missense Glu298Asp Variants2000
  3. 3High CA repeat numbers in intron 13 of the endothelial nitric oxide synthase gene and increased risk of coronary artery disease2000 · 69 citations
  4. 4Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene1993 · 878 citations
  5. 5Nitric oxide and its role in the cardiovascular system1995 · 606 citations