Key result
NOS3 T-786C polymorphism linked to ~26% greater risk of ACS or premature CAD.
Why the study?
The study was conducted to assess the association between the T-786C polymorphism of the nitric oxide synthase 3 (NOS3) gene and acute coronary syndrome or premature coronary artery disease.
Is the T-786C polymorphism of the NOS3 gene associated with an increased risk of acute coronary syndrome or premature coronary artery disease?
Meta-Analysis (n=17,324)
Is the T-786C polymorphism of the NOS3 gene associated with an increased risk of acute coronary syndrome or premature coronary artery disease?
The T-786C polymorphism of the NOS3 gene is significantly associated with an increased risk of acute coronary syndrome and premature coronary artery disease.
Answers are grounded in this paper and cite their sources.
T-786C variant may raise ACS/PCAD risk; supports association but remains hypothesis-generating without prospective validation.
A systematic review and a study level meta-analysis was conducted to assess the association between the T-786C polymorphism of the nitric oxide synthase 3 ( NOS3 ) gene with acute coronary syndrome (ACS) or premature coronary artery disease (PCAD). Online databases of PubMed, EMBASE, MEDLINE, Scopus, Cochrane library and Web of Science were systematically searched, yielding 23 different studies (from 22 articles, involving 17,324 subjects), which were included for quantitative synthesis. Study level odds ratios (ORs) and their 95% confidence intervals (CI) were pooled using random effects, employing a Z test. Pooled results suggested a significant association between T-786C polymorphism and ACS or PCAD through dominant and allelic genetic model comparisons (OR, 1.26, 95% CI, 1.09–1.45, p = 0.001 and OR, 1.26, 95% CI, 1.11–1.43, p = 0.0002 respectively). Leave-one-out sensitivity analysis, in addition to the results for the myocardial infarction endpoint, attested to the robustness of the obtained results. Large, prospective investigations are, however, warranted to confirm the presented findings.
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Rai et al. (2026) conducted a meta-analysis in Acute coronary syndrome (ACS) or premature coronary artery disease (PCAD) (n=17,324). T-786C polymorphism of the NOS3 gene was evaluated on Acute coronary syndrome or premature coronary artery disease (OR 1.26, 95% CI 1.09-1.45, p=0.001). The T-786C polymorphism of the NOS3 gene was significantly associated with acute coronary syndrome or premature coronary artery disease (OR 1.26; 95% CI 1.09-1.45; p=0.001).
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