Key result
The eNOS G894T and T-786C gene polymorphisms are significantly associated with coronary artery disease, with the G894T allelic variant showing an OR of 0.83 (p=0.004).
Why the study?
Are endothelial nitric oxide synthase (eNOS) gene polymorphisms associated with coronary artery disease?
Population
56 genetic association studies evaluating patients with coronary artery disease and controls
Comparison
Endothelial nitric oxide synthase gene… vs Wild-type eNOS gene
Design
Meta-analysis
Authors
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eNOS variants may refine CAD genetic risk models in practice; confirms associations via pooled meta-analysis of candidate genes.
Meta-Analysis
Are endothelial nitric oxide synthase (eNOS) gene polymorphisms associated with coronary artery disease?
Odds Ratio: 0.83
p-value: p=0.004
The eNOS G894T and T-786C gene polymorphisms are significantly associated with an increased risk of coronary artery disease, whereas the 4b/a variant is not.
Jun-yan et al. (2010) conducted a meta-analysis in Coronary artery disease (CAD). eNOS gene polymorphisms (G894T, 4b/a, T-786C) vs. Absence of polymorphisms (wild type) was evaluated on Coronary artery disease (OR 0.83, p=0.004). The eNOS G894T and T-786C gene polymorphisms are significantly associated with coronary artery disease, with the G894T allelic variant showing an OR of 0.83 (p=0.004).
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