Key result
The eNOS 4b/a gene polymorphism was significantly associated with an increased risk of coronary artery disease in homozygote comparisons (OR 1.47; 95% CI 1.16-1.87).
Why the study?
Does the eNOS 4b/a gene polymorphism increase the risk of coronary artery disease?
Meta-Analysis (n=18,919)
Does the eNOS 4b/a gene polymorphism increase the risk of coronary artery disease?
Effect estimate: OR 1.47 (95% CI 1.16-1.87)
The eNOS 4b/a gene polymorphism is associated with an increased risk of developing coronary artery disease, particularly in African populations.
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May support targeted CAD risk assessment in select ancestries; leaves open causal validation and practice change pending prospective data.
Yang et al. (2014) conducted a meta-analysis in Coronary artery disease (CAD) (n=18,919). eNOS 4b/a gene polymorphism was evaluated on Coronary artery disease (CAD) risk (OR 1.47, 95% CI 1.16-1.87). The eNOS 4b/a gene polymorphism was significantly associated with an increased risk of coronary artery disease in homozygote comparisons (OR 1.47; 95% CI 1.16-1.87).
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