Key result
eNOS 4a/b polymorphism shows no association with premature CAD in Caucasian women.
Why the study?
Genetic polymorphism of the eNOS gene has been identified as a risk factor for cardiovascular diseases, but its association with premature CAD in Caucasian women remains unclear.
Does the eNOS 4a/b gene polymorphism increase the risk of premature coronary artery disease or alter lipid parameters in Caucasian women?
Case-Control (n=260)
Does the eNOS 4a/b gene polymorphism increase the risk of premature coronary artery disease or alter lipid parameters in Caucasian women?
Odds Ratio: 0.7 (95% CI 0.2–3.7)
p-value: p=0.7
The eNOS 4a/b gene polymorphism is not a significant independent risk factor for premature coronary artery disease or altered lipid profiles in Caucasian women.
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eNOS 4a allele was associated with premature STEMI; leaves open whether genotyping improves risk stratification beyond conventional factors.
Mitja Letonja (2004) conducted a case-control in Premature coronary artery disease (n=260). eNOS 4a/b polymorphism vs. Absence of polymorphism / other genotypes was evaluated on Premature CAD (OR 0.7, 95% CI 0.2-3.7, p=0.7). The eNOS 4a/b polymorphism was not associated with premature coronary artery disease in Caucasian women (OR 0.7; 95% CI 0.2-3.7; p = 0.7).
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