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May 20, 2011Angiology

Association of Endothelial Nitric Oxide Synthase Gene Variant (G894T) With Coronary Artery Disease in Western Iran

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Key result

The presence of the eNOS GT + TT genotype was associated with a 2.1-fold increased risk of coronary artery disease (P=0.006).

Why the study?

Does the eNOS G894T gene variant increase the risk of coronary artery disease?

Population

299 individuals from Western Iran, comprising 207 unrelated patients with coronary artery disease and 92…

Comparison

Presence of endothelial nitric oxide synthase… vs Absence of the variant (GG genotype or G allele)

Design

Case-control

Authors

ZRZohreh RahimiRNReza Nourozi-Rad

Discussion

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Member takes

Overview

Does not support eNOS genotyping in practice; leaves open its role in CAD risk assessment beyond this population.

Study Design

Type

Case-Control (n=299)

Structured PICO

Does the eNOS G894T gene variant increase the risk of coronary artery disease?

P
Population
299 individuals, including 207 patients with coronary artery disease and 92 controls from Western Iran.
E
Exposure
Presence of endothelial nitric oxide synthase (eNOS) G894T variant (GT + TT genotype or T allele)
C
Comparator
Absence of the variant (GG genotype or G allele)
O
Outcome
Risk of coronary artery disease (CAD)hard clinical

Main Result

Odds Ratio: 2.1

p-value: p=0.006

The eNOS G894T polymorphism (specifically the T allele and GT+TT genotypes) is significantly associated with an increased risk of coronary artery disease in the Western Iranian population.

Cite This Study

Rahimi et al. (2011) conducted a case-control in Coronary Artery Disease (n=299). eNOS G894T variant (GT + TT genotype) vs. Absence of GT + TT genotype was evaluated on Risk of coronary artery disease (OR 2.1, p=0.006). The presence of the eNOS GT + TT genotype was associated with a 2.1-fold increased risk of coronary artery disease (P=0.006).

synapsesocial.com/papers/6a89a4589be9d02581bd71bchttps://doi.org/10.1177/0003319711409741
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Endothelial Nitric Oxide Synthase Gene Is Associated with Coronary Artery Disease: A Meta-Analysis2010 · 42 citations
  2. 2Common Variants of the Endothelial Nitric Oxide Synthase Gene and the Risk of Coronary Heart Disease Among U.S. Diabetic Men2006 · 30 citations
  3. 3Endothelial Nitric Oxide Synthase and Angiotensinogen Gene Polymorphism in Coronary Artery Diseases in Egypt2010 · 20 citations
  4. 4Evidence for association of a common variant of the endothelial nitric oxide synthase gene (Glu<sup>298</sup>→Asp polymorphism) to the presence, extent, and severity of coronary artery disease2002 · 124 citations
  5. 5The Asp298 allele of endothelial nitric oxide synthase is a risk factor for myocardial infarction among patients with type 2 diabetes mellitus2008 · 18 citations