Why the study?
Does the Asp/Asp genotype of the eNOS Glu298-->Asp polymorphism increase the risk and severity of coronary artery disease compared to Glu298 allele carriers?
Population
315 subjects from the Italian population, comprising 201 patients with angiographically defined coronary…
Comparison
Presence of the Asp/Asp genotype of the eNOS… vs Presence of the Glu298 allele in the eNOS gene
Design
Case-control
Authors
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May support genetic risk stratification for CAD; hypothesis-generating and should not yet change practice.
Does the Asp/Asp genotype of the eNOS Glu298-->Asp polymorphism increase the risk and severity of coronary artery disease compared to Glu298 allele carriers?
The eNOS Glu298-->Asp polymorphism, specifically the Asp/Asp genotype, is an independent genetic risk factor for the presence and angiographic severity of coronary artery disease.
Colombo et al. (2002) studied this question.
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