December 1, 2000ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)
Functional gene testing of the Glu298Asp polymorphism of the endothelial NO synthase
Why the study?
Does the Glu298Asp polymorphism of the eNOS gene influence endothelium-dependent vasodilation in patients with normal or elevated cholesterol?
Population
80 patients with normal or elevated cholesterol
Comparison
Glu298Asp polymorphism of the eNOS gene vs Different eNOS genotypes
Design
Cross-sectional
Authors
Discussion
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Member takes
Overview
No clinical role for Glu298Asp testing in endothelial assessment; leaves open effects on other vascular phenotypes.
Structured PICO
Does the Glu298Asp polymorphism of the eNOS gene influence endothelium-dependent vasodilation in patients with normal or elevated cholesterol?
P
Population
80 patients with normal or elevated cholesterol
I
Intervention
Glu298Asp polymorphism of the eNOS gene (position 1917 G/T)
C
Comparator
Different eNOS genotypes
O
Outcome
Endothelium-dependent and -independent vasodilation (forearm blood flow measured by plethysmography in response to intra-arterial acetylcholine, nitroprusside, and L-NMMA)surrogate
The eNOS Glu298Asp polymorphism does not appear to have a biologically relevant effect on endothelium-dependent vasodilation in humans.
Cite This Study
Schneider et al. (2000) studied this question.