Key result
The Asp allele of the ecNOS Glu298Asp polymorphism was associated with a significantly reduced forearm blood flow response to L-NMMA compared to the Glu/Glu genotype (P=0.01).
Why the study?
Does the ecNOS Glu298Asp polymorphism affect basal nitric oxide production in healthy subjects?
Population
41 healthy subjects
Comparison
Presence of the Asp allele of the ecNOS… vs Glu/Glu genotype of the ecNOS Glu298Asp…
Design
Cross-sectional
Authors
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May indicate functional impact of ecNOS polymorphism on basal NO; hypothesis-generating for hypertension mechanisms, no practice change indicated.
Cross-Sectional (n=41)
Does the ecNOS Glu298Asp polymorphism affect basal nitric oxide production in healthy subjects?
p-value: p=0.01
The ecNOS Glu298Asp polymorphism is associated with reduced basal nitric oxide production, providing a potential functional mechanism for its role in hypertension and atherosclerosis.
Veldman et al. (2002) conducted a cross-sectional in Healthy subjects (n=41). Asp allele of the ecNOS Glu298Asp polymorphism vs. Glu/Glu genotype was evaluated on Forearm blood flow response to intra-arterial infusion of L-NMMA (p=0.01). The Asp allele of the ecNOS Glu298Asp polymorphism was associated with a significantly reduced forearm blood flow response to L-NMMA compared to the Glu/Glu genotype (P=0.01).
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