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October 5, 1999Circulation

A Common Variant of the Endothelial Nitric Oxide Synthase (Glu298→Asp) Is a Major Risk Factor for Coronary Artery Disease in the UK

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Why the study?

Is the Glu298-->Asp variant of the NOS 3 gene associated with an increased risk of coronary artery disease and myocardial infarction?

Population

868 individuals across two independent case-control studies in the UK. Study 1: 298 unrelated patients with…

Comparison

Homozygosity for the Asp298 variant of the NOS 3… vs Glu298 homozygotes

Design

Case-control

Authors

AHAroon D. HingoraniUniversité Claude Bernard Lyon 1CLChia Fan LiangUniversity of CambridgeJFJ FatibeneUniversity of Cambridge

Discussion

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Implication

eNOS Asp298 homozygosity may elevate CAD/MI risk; leaves open clinical utility and requires prospective validation.

Structured PICO

Is the Glu298-->Asp variant of the NOS 3 gene associated with an increased risk of coronary artery disease and myocardial infarction?

P
Population
868 individuals across two independent case-control studies in the UK. Study 1 (CHAOS): 298 unrelated patients with positive coronary angiograms and 138 unrelated healthy controls. Study 2 (CHAOS II): 249 patients with recent myocardial infarction and 183 unrelated controls.
I
Intervention
Homozygosity for the Asp298 variant of the NOS 3 gene (894 G-->T polymorphism encoding a Glu298-->Asp amino acid substitution in eNOS)
C
Comparator
Glu298 homozygotes
O
Outcome
Angiographic coronary artery disease (Study 1) and recent myocardial infarction (Study 2)hard clinical

Homozygosity for the Asp298 variant of the eNOS gene is a significant genetic risk factor for angiographic coronary artery disease and myocardial infarction.

Cite This Study

Hingorani et al. (1999) studied this question.

synapsesocial.com/papers/6a7cd7953c7b3e4c163e1393https://doi.org/10.1161/01.cir.100.14.1515
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Endothelial Nitric Oxide Synthase Gene Polymorphism and Acute Myocardial Infarction1998 · 355 citations
  2. 2Lack of Evidence for Linkage of the Endothelial Cell Nitric Oxide Synthase Gene to Essential Hypertension1995 · 162 citations
  3. 3Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene1993 · 878 citations
  4. 4Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults.1996 · 417 citations
  5. 5Effects of Thrombolytic Therapy on Left Ventricular Function and the Importance of Long-Term Patency of the Infarct-Related Artery1995 · 10 citations