What question did this study set out to answer?

To assess whether common genetic variants in the endothelial nitric oxide synthase (eNOS) gene correlate with an elevated risk of carotid artery plaques.

March 1, 2001Stroke

A Common Variant of Endothelial Nitric Oxide Synthase (Glu298Asp) Is an Independent Risk Factor for Carotid Atherosclerosis

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Authors

GLGiuseppe LemboGeneral Cardiology NLNicola De LucaFederico II University Hospital CBCristina BattagliKarolinska Institutet

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Implication

Observational study reveals that eNOS Glu298Asp homozygosity triples carotid plaque risk in hypertensive individuals, indicating genetic susceptibility to vascular disease.

Key Points

To assess whether common genetic variants in the endothelial nitric oxide synthase (eNOS) gene correlate with an elevated risk of carotid artery plaques.
Screened 375 individuals evaluated for arterial hypertension at a single institutional center.
Classified carotid plaques by an intima-media thickness ≥1.5 mm.
Genotyped two intronic polymorphisms (CA and 27-bp repeats) and one exonic polymorphism (Glu298Asp) within the eNOS gene.
Only the Glu298Asp polymorphism demonstrated a statistically significant association with the presence of carotid plaques (P < 0.05).
Homozygosity for the Asp298 variant conferred an approximately threefold increase in the risk of carotid plaques compared with Glu298 homozygosity, independent of age, blood pressure, and smoking.

Cite This Study

Lembo et al. (2001) studied this question.

synapsesocial.com/papers/6a89a45a9be9d02581bd71c2 https://doi.org/10.1161/01.str.32.3.735

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Implication

Observational study reveals that eNOS Glu298Asp homozygosity triples carotid plaque risk in hypertensive individuals, indicating genetic susceptibility to vascular disease.

A Common Variant of Endothelial Nitric Oxide Synthase (Glu298Asp) Is an Independent Risk Factor for Carotid Atherosclerosis

Discussion

Member takes

Implication

Key Points

Cite This Study

A Common Variant of Endothelial Nitric Oxide Synthase (Glu298Asp) Is an Independent Risk Factor for Carotid Atherosclerosis

Discussion

Member takes

Implication

Key Points

Cite This Study

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