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June 13, 2010Angiology

Endothelial Nitric Oxide Synthase and Angiotensinogen Gene Polymorphism in Coronary Artery Diseases in Egypt

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Key result

The angiotensinogen (AGT) TT allele was significantly more frequent in patients with coronary artery disease compared to healthy controls (22% vs 6%, P < .05).

Why the study?

Are eNOS (Glu298Asp) and angiotensinogen (M235T) gene polymorphisms associated with coronary artery disease in an Egyptian population?

Population

150 individuals in an Egyptian population, comprising 100 patients with coronary artery disease and 50…

Design

Case-control

Authors

TMTarek K. MotawiOSOlfat ShakerMTMohamed Taha

Discussion

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Member takes

Overview

AGT TT allele associated with CAD in Egyptians; hypothesis-generating and should not yet change risk assessment.

Study Design

Type

Case-Control (n=150)

Structured PICO

Are eNOS (Glu298Asp) and angiotensinogen (M235T) gene polymorphisms associated with coronary artery disease in an Egyptian population?

P
Population
150 individuals from Egypt, comprising 100 patients with coronary artery disease and 50 healthy controls.
O
Outcome
Association of endothelial nitric oxide (eNOS) polymorphism (Glu298Asp) and angiotensinogen polymorphisms (M235T) with coronary artery diseasesurrogate

Main Result

Absolute Event Rate: 22% vs 6%

p-value: p=<.05

Homozygosity for eNOS Glu298Asp and AGT M235T polymorphisms is associated with an increased risk of coronary artery disease in the Egyptian population.

Cite This Study

Motawi et al. (2010) conducted a case-control in Coronary Artery Disease (n=150). eNOS (Glu298Asp) and angiotensinogen (M235T) gene polymorphisms vs. Healthy controls was evaluated on Frequency of angiotensinogen (AGT) TT allele (p=<.05). The angiotensinogen (AGT) TT allele was significantly more frequent in patients with coronary artery disease compared to healthy controls (22% vs 6%, P < .05).

synapsesocial.com/papers/6a89a4589be9d02581bd71bfhttps://doi.org/10.1177/0003319710373094
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1NO Level and Endothelial NO Synthase Gene Polymorphism (Glu298Asp) in the Patients with Coronary Artery Disease from the Turkish Population2004 · 43 citations
  2. 2Evidence for association of a common variant of the endothelial nitric oxide synthase gene (Glu<sup>298</sup>→Asp polymorphism) to the presence, extent, and severity of coronary artery disease2002 · 124 citations
  3. 3A Common Variant of the Endothelial Nitric Oxide Synthase (Glu<sup>298</sup>→Asp) Is a Major Risk Factor for Coronary Artery Disease in the UK1999 · 531 citations
  4. 4Lack of association of the Glu298Asp polymorphism of endothelial nitric oxide synthase with manifest coronary artery disease, carotid atherosclerosis and forearm vascular reactivity in two Austrian populations2003 · 37 citations
  5. 5The Glu298Asp polymorphism in the endothelial nitric oxide synthase gene is strongly associated with coronary spasm2003 · 60 citations