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September 1, 2018The Egyptian Heart JournalOpen Access

Endothelial nitric oxide synthase Glu 298 Asp (G894T) and Apolipoprotein E gene polymorphism as possible risk factors for coronary heart disease among Egyptians

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Why the study?

Are eNOS (Glu298Asp) and ApoE gene polymorphisms associated with an increased risk of coronary heart disease in Egyptians?

Population

200 Egyptian individuals, comprising 100 coronary heart disease cases and 100 age- and sex-matched healthy…

Comparison

Presence of eNOS and ApoE gene polymorphisms vs Absence of these specific polymorphisms

Design

Case-control

Authors

SASherif ArafaSASherehan AbdelsalamAEAbdel‐Hady El‐Gilany

Discussion

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Overview

Highlights potential novel genetic markers for CHD in Egyptians; leaves open their prognostic value pending validation.

Structured PICO

Are eNOS (Glu298Asp) and ApoE gene polymorphisms associated with an increased risk of coronary heart disease in Egyptians?

P
Population
200 Egyptian individuals, comprising 100 coronary heart disease (CHD) cases and 100 age- and sex-matched healthy controls.
I
Intervention
Presence of eNOS (Glu298Asp) and ApoE gene polymorphisms
C
Comparator
Absence of these specific polymorphisms (healthy controls)
O
Outcome
Association with coronary heart disease (CHD)

eNOS (Glu298Asp) and ApoE gene polymorphisms, particularly in combination, are significant genetic risk factors for coronary heart disease in the Egyptian population.

Cite This Study

Arafa et al. (2018) studied this question.

synapsesocial.com/papers/6a70ac823ce530166bc2e4dchttps://doi.org/10.1016/j.ehj.2018.08.001
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Coronary Artery Ectasia Is Associated with the c.894G>T (Glu298Asp) Polymorphism of the Endothelial Nitric Oxide Synthase Gene2014 · 13 citations
  2. 2Apolipoprotein E and Carotid Artery Atherosclerosis2001 · 82 citations
  3. 3Lack of Association Between Matrix Metalloproteinase-9 and Endothelial Nitric Oxide Synthase Gene Polymorphisms and Coronary Artery Disease in Turkish Population2009 · 36 citations
  4. 4Genetic Markers of Myocardial Infarction2012 · 4 citations
  5. 5Heart disease and stroke statistics--2015 update: a report from the American Heart Association.2015 · 8,330 citations