Key result
The presence of the T allele of the NOS-3 gene was associated with a 2.15 times increased risk of coronary heart disease.
Why the study?
Does the NOS-3 G894T polymorphism increase the risk of coronary heart disease?
Population
Patients with coronary heart disease and controls
Comparison
Presence of the NOS-3 G894T polymorphism vs Absence of the T allele (controls)
Design
Editorial
Authors
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May support genetic risk stratification for CHD prevention; leaves open whether NOS-3 testing improves outcomes or warrants clinical adoption.
Does the NOS-3 G894T polymorphism increase the risk of coronary heart disease?
Effect estimate: 2.15 times increased risk
The NOS-3 G894T polymorphism may serve as a useful genetic marker to identify individuals prone to developing coronary heart disease.
Kolovou et al. (2012) conducted an editorial in Coronary heart disease (CHD). NOS-3 G894T polymorphism (T allele) vs. Controls was evaluated on Coronary heart disease (2.15 times increased risk). The presence of the T allele of the NOS-3 gene was associated with a 2.15 times increased risk of coronary heart disease.
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