Key result
Isoproterenol administration in beagle dogs caused a time-dependent and monophasic increase in cardiac troponins and CK, with limited additional release upon a second dose.
Population
2 beagle dogs (1 male, 1 female, 9 months old)
Design
Preclinical
Follow-up
24 hours after the second daily dose
Authors
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Supports troponin as time-dependent marker in beagle dog cardiotoxicity models; leaves open translation to human drug safety assessment.
Cardiac troponins provide a reliable, time-dependent marker for drug-induced cardiac injury in beagle dog models, with a wider diagnostic window than creatine kinase.
Feng et al. (2005) studied Isoproterenol-induced cardiac injury (n=2). Isoproterenol was evaluated on Release of cardiac troponins (cTnI and cTnT) and CK. Isoproterenol administration in beagle dogs caused a time-dependent and monophasic increase in cardiac troponins and CK, with limited additional release upon a second dose.
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