Key result
Peripheral low-concentration norepinephrine during major noncardiac surgery increased intraoperative systolic blood pressure relative to target compared to placebo (MD 7.1 mm Hg; 95% CI 0.2-14.0).
Why the study?
Intra- and postoperative hypotension prevention is important, and peripheral low-concentration norepinephrine may be safe and effective to reduce this risk.
Does peripheral low-concentration norepinephrine infusion safely and feasibly maintain systolic blood pressure in adult patients undergoing major noncardiac surgery?
RCT (n=60)
Blinded
Randomized
Yes
Does peripheral low-concentration norepinephrine infusion safely and feasibly maintain systolic blood pressure in adult patients undergoing major noncardiac surgery?
Mean Difference: 7.1 (95% CI 0.2–14)
Absolute Event Rate: 10% vs 2.9%
No takes yet. Share an insight, caveat, or question.
Peripheral administration of low-concentration norepinephrine during major noncardiac surgery is feasible, safe, and effectively maintains intraoperative systolic blood pressure targets.
A 2021 study conducted an RCT in Major noncardiac surgery (n=60). Peripheral low-concentration norepinephrine vs. Placebo (saline 0.9%) was evaluated on Difference between achieved intraoperative systolic blood pressure and preselected minimum target (MD 7.1, 95% CI 0.2-14.0). Peripheral low-concentration norepinephrine during major noncardiac surgery increased intraoperative systolic blood pressure relative to target compared to placebo (MD 7.1 mm Hg; 95% CI 0.2-14.0).
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