Key result
A pyrolytic carbon hemiarthroplasty implant demonstrated superior in vivo histologic response compared to a Co-Cr alloy implant, with significantly improved tibial cartilage scores at 52 weeks (21.9 vs 16.7, p<0.001).
Why the study?
Does a pyrolytic carbon implant improve histologic response compared to a Co-Cr alloy implant in a canine model of focal osteochondral defects?
Does a pyrolytic carbon implant improve histologic response compared to a Co-Cr alloy implant in a canine model of focal osteochondral defects?
Absolute Event Rate: 21.9% vs 16.7%
p-value: p=<0.001
In a canine model, a pyrolytic carbon implant for focal cartilage defects demonstrated superior in vivo histologic response and less cartilage degeneration compared to a Co-Cr alloy implant.
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Promising in canine models; leaves open translation of pyrolytic carbon hemiarthroplasty to human focal defects.
Salkeld et al. (2016) studied Focal osteochondral defects in the medial femoral condyle (n=9). Pyrolytic carbon hemiarthroplasty implant vs. Cobalt-chromium (Co-Cr) alloy implant was evaluated on Mean total histologic score of the tibial articular cartilage at 52 weeks (p=<0.001). A pyrolytic carbon hemiarthroplasty implant demonstrated superior in vivo histologic response compared to a Co-Cr alloy implant, with significantly improved tibial cartilage scores at 52 weeks (21.9 vs 16.7, p<0.001).
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