Key result
Numerical simulations of myocardial ischemia in anisotropic cardiac models demonstrated that extracellular potential patterns during the ST interval differ from those in stationary models.
Non-stationary computational models reveal different extracellular potential patterns during the ST interval compared to traditional stationary models, providing new insights into the electrophysiological markers of subendocardial ischemia.
Non-stationary models yield distinct ST potentials in ischemia simulations; leaves open clinical ECG translation.
The interaction between the presence of moderate or severe subendocardial ischemic regions and the anisotropic structure of the cardiac muscle is investigated here by means of numerical simulations based on anisotropic Bidomain and Monodomain models. The ischemic effects on cardiac excitation, recovery and distribution of action potential duration are discussed, showing the presence of ischemic epicardial markers. Extracellular potential distributions during the ST and TQ intervals are computed separately using non-stationary models. During the ST interval, the extracellular potential patterns differ from those simulated with stationary models used in the literature. These differences are explained by decomposing the cardiac current sources into conormal, axial and orthogonal components and by determining which component is dominant during the ST and TQ intervals.
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Franzone et al. (2007) studied Myocardial ischemia. Moderate or severe subendocardial ischemic regions (simulation) vs. Stationary models was evaluated on Extracellular potential distributions during the ST and TQ intervals. Numerical simulations of myocardial ischemia in anisotropic cardiac models demonstrated that extracellular potential patterns during the ST interval differ from those in stationary models.
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