Key result
Among 40 patients with systemic sclerosis, 5 (12.5%) were found to have severe tri-leaflet degenerative aortic stenosis, suggesting premature onset is not uncommon in this population.
Why the study?
Cardiovascular involvement is a known complication linked to poor prognosis in systemic sclerosis, but few reports have examined valvular heart disease in these patients.
Case Report (n=40)
No
Premature-onset severe degenerative tri-leaflet aortic stenosis is not uncommon in patients with systemic sclerosis, highlighting the need for careful evaluation of valvular disease and frailty in this population.
Prompts heightened echocardiographic vigilance for premature aortic stenosis in systemic sclerosis; leaves open the true prevalence and.
Although cardiovascular involvement is a well-known complication correlated with a poor prognosis in patients with systemic sclerosis, there are few reports on valvular heart disease. Forty patients with systemic sclerosis were retrospectively analyzed. Valvular heart disease was found in six patients, five of whom had severe tri-leaflet aortic stenosis. Three of these 5 patients were ≤71 years old. Two frail elderly patients who underwent transcatheter aortic valve replacement died within two years. Premature-onset aortic stenosis is not uncommon in patients with systemic sclerosis. When considering mechanical intervention, the evaluation of frailty is important.
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Machida et al. (2020) conducted a case report in Systemic Sclerosis (n=40). Systemic Sclerosis was evaluated on Prevalence of severe tri-leaflet aortic stenosis. Among 40 patients with systemic sclerosis, 5 (12.5%) were found to have severe tri-leaflet degenerative aortic stenosis, suggesting premature onset is not uncommon in this population.
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