Key result
Pregnant women with Marfan syndrome who underwent prophylactic aortic root replacement had a higher rate of peripartum type B aortic dissection than those without prior replacement (60% vs 10%; P<0.05).
Why the study?
Does prophylactic aortic root replacement prevent peripartum type B aortic dissection in pregnant women with Marfan syndrome?
Population
14 pregnant women fulfilling the revised Ghent nosology criteria for Marfan syndrome, managed at a single…
Comparison
Prophylactic aortic root replacement before… vs No prophylactic aortic root replacement before…
Design
Case_series
Follow-up
Throughout the peripartum period
Authors
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Type B dissection risk persists after ARR in Marfan pregnancies; case report leaves open preventive benefit and requires confirmation.
Observational (n=14)
No
Does prophylactic aortic root replacement prevent peripartum type B aortic dissection in pregnant women with Marfan syndrome?
Absolute Event Rate: 60% vs 10%
p-value: p=<0.05
Pregnant patients with Marfan syndrome who have undergone prophylactic aortic root replacement remain at high risk for type B aortic dissection during the peripartum period.
Sayama et al. (2017) conducted an observational in Marfan syndrome (n=14). Prophylactic aortic root replacement (ARR) vs. No prophylactic aortic root replacement was evaluated on Type B aortic dissection during the peripartum period (p=<0.05). Pregnant women with Marfan syndrome who underwent prophylactic aortic root replacement had a higher rate of peripartum type B aortic dissection than those without prior replacement (60% vs 10%; P<0.05).
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