Why the study?
Does pregnancy alter the distensibility and compliance of the thoracic aorta in conscious rats?
Population
17 conscious rats (9 pregnant, 8 nonpregnant matched for age and days postsurgery)
Comparison
Pregnancy vs Nonpregnant rats matched for age and days…
Design
Preclinical
Follow-up
20 days
Authors
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Rat aortic adaptations precede BP changes; hypothesis-generating for gestational hemodynamics and requires human validation.
Does pregnancy alter the distensibility and compliance of the thoracic aorta in conscious rats?
Pregnancy induces early increases in aortic compliance and distensibility in rats, which precedes the drop in diastolic blood pressure and may serve to prevent a rise in arterial wall stress.
Slangen et al. (1997) studied this question.
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