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June 1, 2000Ultrasound in Obstetrics and GynecologyOpen Access

Maternal cardiac systolic and diastolic function: relationship with uteroplacental resistances. A Doppler and echocardiographic longitudinal study

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Population

43 healthy normotensive primigravidae

Design

Cohort

Follow-up

Up to 33 +/- 1 weeks of gestation

Authors

HVHerbert ValensiseCross-Cutting CardiologyGNG. P. NovelliPoliclinico Tor VergataBVB. VasapolloUniversity of Rome Tor Vergata

Discussion

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Implication

Diastolic assessment in pregnancy requires gestation-specific norms; leaves open predictive value for adverse outcomes in observational data.

Key Points

  • To evaluate the longitudinal relationship between central maternal cardiac hemodynamic parameters and peripheral uteroplacental resistance throughout normal pregnancy.
  • Longitudinal study of 43 healthy normotensive primigravidae.
  • Conducted maternal echocardiography and uterine artery color Doppler examinations across three gestational stages (12 ± 1, 21 ± 1, and 33 ± 1 weeks).
  • Uterine resistance index decreased from the first to second trimester (0.72 ± 0.10 vs 0.54 ± 0.09, P < 0.001), while left ventricular mass increased from 132 ± 18 g to 174 ± 27 g (P < 0.001).
  • Left ventricular isovolumetric relaxation time decreased across pregnancy (88.7 ± 6.7 ms to 71.1 ± 5.0 ms, P < 0.001) and correlated with left atrial dimensions (r = -0.38, P < 0.001) and uterine resistance index (r = 0.47, P < 0.001).

Structured PICO

P
Population
43 healthy normotensive primigravidae
I
Intervention
Longitudinal evaluation with uterine artery color Doppler and maternal echocardiography at 12 +/- 1, 21 +/- 1, and 33 +/- 1 weeks of gestation
O
Outcome
Relationship between central and peripheral hemodynamic parameters (maternal echocardiographic and uteroplacental resistance modifications)surrogate

Diastolic cardiac function varies during normal pregnancy, with modifications in preload and afterload correlating with changes in left ventricular relaxation.

Cite This Study

Valensise et al. (2000) studied this question.

synapsesocial.com/papers/6a1cd0c41fbf86d1e875c8ebhttps://doi.org/10.1046/j.1469-0705.2000.00135.x

Topics

Echocardiography
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Maternal left ventricular diastolic and systolic long-axis function during normal pregnancy2007 · 96 citations
  2. 2Deterioration in cardiac systolic and diastolic function late in normal human pregnancy2008 · 61 citations
  3. 3Adaptive mechanisms of left ventricular diastolic function to the physiologic load of pregnancy2002 · 45 citations
  4. 4Changes in hemodynamics, ventricular remodeling, and ventricular contractility during normal pregnancy: A longitudinal study1997 · 130 citations
  5. 5Maternal Cardiovascular Function in Normal Pregnancy2016 · 283 citations