Why the study?
Does pseudopregnancy induce similar early hemodynamic adaptations as normal pregnancy in rats?
Population
Chronically instrumented, conscious pseudopregnant rats, virgin rats, and previously studied pregnant rats
Comparison
Pseudopregnancy (absence of trophoblast) vs Virgin rats and previously studied pregnant rats
Design
Preclinical
Follow-up
Up to day 20 postmating
Authors
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Pseudopregnancy elicits early rat hemodynamic shifts without trophoblast; leaves open whether similar mechanisms operate in human pregnancy.
Does pseudopregnancy induce similar early hemodynamic adaptations as normal pregnancy in rats?
The trophoblast is not essential for the initial hemodynamic adaptations in rat pregnancy, as pseudopregnancy induces similar changes including increased cardiac output and stroke volume.
Slangen et al. (1996) studied this question.
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