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December 1, 1979Clinical Science

Circulatory Changes during Pregnancy in Spontaneously and Renal Hypertensive Rats

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Why the study?

How do circulatory changes and utero-placental blood supply during pregnancy differ between normotensive, spontaneously hypertensive, and renal hypertensive rats?

Population

Normotensive control rats, spontaneously hypertensive rats, rats with short-standing renal hypertension…

Comparison

Pregnancy in the setting of different… vs Normotensive pregnant rats and non-pregnant…

Design

Preclinical

Follow-up

Evaluated 2 days before expected birth

Authors

YLYen LundgrenSahlgrenska University HospitalKKK. KarlssonUppsala UniversityULUlf LjungbladUniversity of Oslo

Discussion

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Overview

Renal hypertension blunts pregnancy hemodynamics in rats; leaves open translation to human hypertensive pregnancy disorders.

Structured PICO

How do circulatory changes and utero-placental blood supply during pregnancy differ between normotensive, spontaneously hypertensive, and renal hypertensive rats?

P
Population
Normotensive control (NC) rats, spontaneously hypertensive (SH) rats, rats with short-standing renal hypertension induced early in pregnancy, and rats with established renal hypertension induced 4 weeks before pregnancy, evaluated 2 days before expected birth, with non-pregnant rats as controls.
I
Intervention
Pregnancy in the setting of different hypertension models (spontaneous, short-standing renal, established renal)
C
Comparator
Normotensive pregnant rats and non-pregnant control rats
O
Outcome
Mean arterial pressure, heart rate, cardiac output, stroke volume, total peripheral resistance (TPR), utero-placental blood supply, and foetal weightssurrogate

Established renal hypertension in rats prevents normal pregnancy-induced circulatory adaptations and severely reduces utero-placental blood flow, highlighting the impact of chronic hypertension on pregnancy hemodynamics.

Cite This Study

Lundgren et al. (1979) studied this question.

synapsesocial.com/papers/6a8ac8e8f71b672e3df446ebhttps://doi.org/10.1042/cs057337s

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of hypertension on maternal adaptations to pregnancy: experimental study on spontaneously hypertensive rats2001 · 15 citations
  2. 2NEUROVASCULAR FUNCTION DURING PREGNANCY IN THE SPONTANEOUSLY HYPERTENSIVE RAT1992 · 7 citations
  3. 3Maternal Adaptation in Pregnant Hypertensive Rats: Improvement of Vascular and Inflammatory Variables and Oxidative Damage in the Kidney2009 · 20 citations
  4. 4Pregnancy: Its Effects on Blood Pressure, Heart Rate and Sympatho-Adrenal Activity in Spontaneously Hypertensive Rats1978 · 13 citations
  5. 5Role of renin–angiotensin system and oxidative status on the maternal cardiovascular regulation in spontaneously hypertensive rats2012 · 9 citations