Key result
Pregnancy in spontaneously hypertensive rats was associated with impaired maternal volume expansion and significantly affected reproductive outcomes compared to normotensive rats.
Population
50 ten to twelve-week-old virgin female normotensive Wistar-Kyoto rats and spontaneously hypertensive rats
Comparison
Pregnancy in spontaneously hypertensive rats (SHR) vs Pregnancy in normotensive Wistar-Kyoto rats, and…
Design
Preclinical
Follow-up
Duration of pregnancy
Authors
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Validates SHR model for hypovolemic maternal hypertension; leaves open translation to human pregnancy outcomes.
The spontaneously hypertensive rat (SHR) strain serves as a model for chronic hypovolemic maternal hypertension, demonstrating that fetal growth retardation is determined by this hypovolemic state.
Peraçoli et al. (2001) studied Hypertension in pregnancy (n=50). Pregnancy vs. Non-pregnant state was evaluated on Blood pressure, maternal volume expansion, and perinatal outcome. Pregnancy in spontaneously hypertensive rats was associated with impaired maternal volume expansion and significantly affected reproductive outcomes compared to normotensive rats.
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