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January 19, 2012American Journal of Hypertension

Role of renin–angiotensin system and oxidative status on the maternal cardiovascular regulation in spontaneously hypertensive rats

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Population

Spontaneously hypertensive rats and normotensive Wistar controls in the 20th day of pregnancy or age-matched…

Comparison

Pregnancy (evaluated at the 20th day) vs Age-matched nonpregnant rats (SHR-NP and W-NP)

Design

Preclinical

Follow-up

20 days

Authors

DODayane Teixeira OgnibeneUniversidade do Estado do Rio de JaneiroLCLaı́s de CarvalhoUniversidade Federal do Rio de JaneiroCCCristiane Aguiar da CostaUniversidade do Estado do Rio de Janeiro

Discussion

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Implication

Pregnancy-induced BP reduction in rat models merits mechanistic study; leaves open translation to human gestational hypertension.

Structured PICO

P
Population
Spontaneously hypertensive rats (SHR) and normotensive Wistar controls in the 20th day of pregnancy or age-matched nonpregnant rats
I
Intervention
Pregnancy (evaluated at the 20th day)
C
Comparator
Age-matched nonpregnant rats (SHR-NP and W-NP)
O
Outcome
Blood pressure, mesenteric arterial bed reactivity, mesenteric oxidative damage, protein expression, and antioxidant activitiessurrogate

Pregnancy reduces blood pressure in spontaneously hypertensive rats, likely due to increased NO production, enhanced vasorelaxation to Ang II and Ang-(1-7), and decreased vascular ACE and AT1 receptor expression.

Cite This Study

Ognibene et al. (2012) studied this question.

synapsesocial.com/papers/6a718d35f44fa9f079df5550https://doi.org/10.1038/ajh.2011.253

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Possible role of P-450 metabolite of arachidonic acid in vasodilator mechanism of angiotensin II type 2 receptor in the isolated microperfused rabbit afferent arteriole.1997 · 175 citations
  2. 2Angiotensin-(1-7) Dilates Canine Coronary Arteries Through Kinins and Nitric Oxide1996 · 405 citations
  3. 3Enhanced expression of Ang-(1-7) during pregnancy2004 · 128 citations
  4. 4Pregnancy Enhances the Angiotensin (Ang)-(1–7) Vasodilator Response in Mesenteric Arteries and Increases the Renal Concentration and Urinary Excretion of Ang-(1–7)2003 · 49 citations
  5. 5Angiotensin AT1/AT2 Receptors: Regulation, Signalling and Function2003 · 459 citations