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November 1, 1993British Journal of PharmacologyOpen Access

Nitric oxide‐mediated changes in vascular reactivity in pregnancy in spontaneously hypertensive rats

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Population

18-20 day pregnant spontaneously hypertensive rats, nonpregnant SHR, and gestation matched normotensive…

Comparison

NG-nitro-L-arginine (L-NOARG) 5 mg kg-1, i.v. vs Nonpregnant SHR and pregnant normotensive WKY…

Design

Preclinical

Authors

ZCZ. M. ChuHonghu Hospital of Traditional Chinese MedicineLBLawrence J. BeilinGeneral / Preventive / Lipids

Discussion

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Overview

Implicates endothelial NO in pregnancy vasodilation of hypertensive rats; leaves open contribution to pre-eclampsia risk in women.

Structured PICO

P
Population
18-20 day pregnant spontaneously hypertensive rats (SHR), nonpregnant SHR, and gestation matched normotensive Wistar-Kyoto (WKY) rats
I
Intervention
NG-nitro-L-arginine (L-NOARG) 5 mg kg-1, i.v.
C
Comparator
Nonpregnant SHR and pregnant normotensive WKY rats; baseline state before L-NOARG administration
O
Outcome
Changes in vascular reactivity (mean blood pressure, basal perfusion pressure, and vasoconstrictor responses to electrical stimulation, noradrenaline, and angiotensin II) in in situ blood-perfused mesenteric resistance vesselssurrogate

Pregnancy-induced vasodilatation in hypertensive rats is highly dependent on endothelial nitric oxide, suggesting a potential mechanism for the development of pre-eclampsia in women with essential hypertension.

Cite This Study

Chu et al. (1993) studied this question.

synapsesocial.com/papers/6a917ed3d613fa9f3b4667fahttps://doi.org/10.1111/j.1476-5381.1993.tb13939.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Circulatory Changes during Pregnancy in Spontaneously and Renal Hypertensive Rats1979 · 27 citations
  2. 2Angiotensin II receptor alterations during pregnancy in rabbits1986 · 28 citations
  3. 3SEQUENTIAL CHANGES IN THE HUMAN RENIN‐ANGIOTENSIN SYSTEM FOLLOWING DELIVERY1978 · 17 citations
  4. 4NEUROVASCULAR FUNCTION DURING PREGNANCY IN THE SPONTANEOUSLY HYPERTENSIVE RAT1992 · 7 citations
  5. 5Endothelium-dependent contractions to acetylcholine in the aorta of the spontaneously hypertensive rat.1986 · 881 citations